Peer-Reviewed Study in Nature Scientific Reports Demonstrates Non-Invasive Fat Reduction Using Alma's Energy-Based Technology

CAESAREA, Israel, June 18, 2025 /PRNewswire/ -- A newly published, peer-reviewed study in Nature Scientific Reports, part of the prestigious Nature Portfolio, presents compelling clinical evidence on the effectiveness of non-invasive energy-based technology for abdominal fat reduction. The study demonstrated statistically significant decreases in abdominal fat layer thickness in Korean women with abdominal obesity, following a series of ultrasound and radiofrequency treatments using Alma's Accent Prime platform.

Combines proprietary ultrasound and radiofrequency technologies to deliver personalized, non-invasive body contouring treatments: Accent Prime (Credit: Alma PR)

Conducted at Ewha Womans University Seoul Hospital by Dr. Yeo Ju Sohn and Dr. Hyejin Chun of the Department of Family Medicine at Ewha Womans University College of Medicine, the research confirmed measurable fat layer reduction through ultrasound imaging and waist circumference assessments. Patients reported high satisfaction and consistently strong tolerance throughout the treatment protocol, with no adverse events observed.

This publication comes at a time when abdominal obesity is increasingly recognized as a key contributor to cardiovascular disease and metabolic syndrome, both in South Korea and globally. According to the World Health Organization, more than 1 billion people worldwide are living with obesity—a major risk factor for type 2 diabetes, cardiovascular disease, and premature mortality. As obesity rates continue to rise, so does the urgency for safe, effective, and accessible treatment options beyond surgical intervention.

"This study highlights the evolving role of non-invasive modalities in body shaping and reinforces their potential significance in the broader context of health and wellness," said Lior Dayan, CEO of Alma. "This new publication strengthens the scientific foundation supporting Alma's technologies and showcases our commitment to advancing innovation that prioritizes patient safety, enhances the treatment experience, and keeps pace with the evolving needs of modern patients."

Accent Prime combines proprietary ultrasound and radiofrequency technologies to deliver personalized, non-invasive treatments for body contouring, skin tightening, and facial rejuvenation. The platform is CE marked and approved for the treatment of various different indications, including facial and body contouring, skin tightening, cellulite reduction, and skin rejuvenation. Widely adopted by leading clinics worldwide, Accent Prime offers flexible, combination-based protocols that support tailored treatment strategies across diverse skin types and body areas—without the need for surgery or downtime. These proprietary ultrasound and radiofrequency technologies have also been clinically validated in other products from Alma's Body Contouring series, such as Alma PrimeX.

About Alma

Alma is a global leader in medical aesthetic solutions, with over 25 years of innovation. We empower practitioners to deliver safe, effective, and life-transforming treatments to their patients, utilizing state-of-the-art, clinically proven solutions such as energy-based device lasers, diagnostics, injectables, and advanced skincare. Alma's multiple award-winning products have set a new benchmark in the medical aesthetic industry, both in terms of clinical excellence and groundbreaking innovations.

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